Inhibition of rat liver microsomal fatty acid chain elongation by gemfibrozil in vitro

FEBS Letters

Alegret, M.¹  Laguna, J.C.¹  Adzet, T.¹  Sánchez, R.M.¹  Merlos, M.¹  Vázquez, M.¹  Viñals, M.¹ 

[1] Unidad de Farmacología y Farmacognosia, Dept. Farmacología y Química Terapéutica, Facultad de Farmacia, Barcelona 08028, Spain

关键词: Gemfibrozil;    Fatty acid elongation system;    Condensing enzyme;    Hypolipidemic drug;   

DOI  :  10.1016/0014-5793(92)80170-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Gemfibrozil, a hypolipidemic drug mainly used in the treatment of hypertriglyceridemic states, strongly inhibits the rat hepatic microsomal fatty acid chain elongation system in vitro. The inhibition is independent on the reducing cofactor used in the assay. Furthermore, gemfibrozil seems to act by inhibiting the rate-limiting step of the elongation process, the condensing reaction, without discriminating among the proposed three different condensing enzymes, devoted to condensation of saturated, mono-unsaturated and polyunsaturated acyl-CoA substrates.

【 授权许可】

Unknown