Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid βoxidation

FEBS Letters

Völkl, A.¹  Fahimi, H.D.¹  Baumgart, E.¹  Pill, J.² 

[1] Department of Anatomy and Cell Biology II, University of Heidelberg, Heidelberg, FRG;Medical Research Department, Boehringer Mannheim, Mannheim, FRG

关键词: Peroxisome proliferation;    Lipid β-oxidation;    Hypolipidemic drug;   

DOI  :  10.1016/0014-5793(90)80750-D

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Marked proliferation of rat hepatic peroxisomes is observed after treatment with a new potent hypolipidemic drug BM 15766, as well as after bezafibrate. Whereas the relative specific activity of the peroxisomal fatty acid βoxidation system is not affected by BM 15766 it is significantly increased after bezafibrate. This is also confirmed by immunoblot analysis of individual β-oxidation enzymes in highly purified peroxisome fractions. These observations suggest that peroxisome proliferation and the induction of the fatty acid β-oxidation are regulated separately.

【 授权许可】

Unknown