Voltage‐dependent calcium entry in confluent bovine capillary endothelial cells

FEBS Letters

Elhamdani, A.¹  Bossu, J.L.¹  Feltz, A.¹ 

[1] Laboratoire d'Etude des Régulations Physiologiques, CNRS associé à l'Université Louis Pasteur, 23 rue Becquerel, F-67087 Strasbourg cedex, France

关键词: Confluent endothelial cell;    Calcium channel;    Bovine;   

DOI  :  10.1016/0014-5793(92)80123-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Confluent bovine capillary endothelial cells display, when examined for voltage-dependent calcium entries using cell-attached channel recordings, two types of Ca²⁺ channels (4 and 23.5 pS in 110 mM Ba²⁺) both sensitive to the dihydropyridine Ca agonist BAY K 8644. In contrast to isolated cells, confluent cells display no T-type, low threshold activity, and Ca currents were typically only elicited at very depolarized potentials. In these cells, voltage-dependent calcium entries will only be made operative by substances able to shift their activation towards the resting potential.

【 授权许可】

Unknown