Interaction of cholesterol‐conjugated alkylating oligonucleotide derivatives with cellular biopolymers

FEBS Letters

Zarytova, V.F.¹  Karamyshev, V.N.¹  Ryte, A.S.¹  Vlassov, V.V.¹  Ivanova, E.M.¹  Guskova, Z.V.¹  Nechaeva, M.V.¹ 

[1] Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk 630090, USSR

关键词: Oligonucleotide derivative;    Cellular uptake;    Affinity modification;   

DOI  :  10.1016/0014-5793(92)80229-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interactions of oligonucleotide derivatives with mammalian cells and cellular biopolymers have been investigated. The derivatives were oligonucleotides bearing an alkylating 2-chloroethylamino group at the 3′-end and a cholesterol residue at the 5′-terminal phosphate. These compounds are readily taken up by cells and react with cellular DNA, RNA and some proteins which may play a role in delivery of the compounds into cells.

【 授权许可】

Unknown