The importance of C‐terminal amino acid residues of actin to the inhibition of actomyosin ATPase activity by caldesmon and troponin I

FEBS Letters

Kołakowski, Janusz¹  Dąbrowska, Renata¹  Makuch, Robert¹ 

[1] Department of Muscle Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland

关键词: Caldesmon;    Troponin;    C-Terminus of actin;    Actomyosin ATPase;   

DOI  :  10.1016/0014-5793(92)80546-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Proteolytic elimination of three C-terminal amino acid residues from actin weakens its interaction with caldesmon and troponin I and, in consequence, lowers the inhibitory effects of both proteins on actomyosin ATPase activity. These results prove the importance of C-terminal extremity of actin to the overall interaction of this protein with caldesmon and troponin I.

【 授权许可】

Unknown