Inhibition of trypsin by the β‐amyloid protein precursor

FEBS Letters

Van der Elst, L.¹  Octave, J.-N.¹  Delvaux, A.¹ 

[1] Laboratoire de Neurochimie, Université, Catholique, de Louvain, Clos Chapelle, aux Champs 30, B-1200 Brussels, Belgium

关键词: β-Amyloid precursor;    Charge separation;    Inhibition of serine protease;   

DOI  :  10.1016/0014-5793(92)80341-D

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Soluble β-amyloid protein precursors (β-APPs) were studied in human brain and cerebrospinal fluid (CSF) after partial purification by ion exchange chromatography. Proteins were analysed in immunoblotting experiments using a monoclonal antibody directed against the N-terminal segment or the β-APP 770, and by reverse enzymography. In the human brain and CSF, a protein which comigrates with the β-APP 770 expressed by transfected CHO cells was able to inhibit trypsin.

【 授权许可】

Unknown