Interaction of a synthetic peptide of the interferon α2 C‐terminal part with human blood leukocytes. II. Effect on protein tyrosine phosphorylation

FEBS Letters

Bulargina, T.V.¹  Kirkin, A.F.¹  Shevalier, A.F.²  Kharitonenkov, A.I.¹  Kolosova, O.V.¹  Danilkovich, A.V.¹  Gusev, M.V.¹  Freze, K.V.¹ 

[1] Moscow State University, Biological Faculty, 119899 Moscow, USSR;M.M. Shemyakin Institute of Bioorganic Chemistry, The USSR Academy of Sciences, 117871 Moscow, USSR

关键词: Interferon α2;    Synthetic peptide;    Human;    Lymphocyte;    Tyrosine phosphorylation;    Monoclonal antibody;    ConA;    concanavalin A;    IFNα2;    interferon α2;    PBMC;    peripheral blood mononuclear cells;    P-Tyr;    phosphotyrosine;    TPK;    tyrosine protein kinase;   

DOI  :  10.1016/0014-5793(92)80302-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Tyrosine phosphorylation in human blood lymphocytes was studied as a function of stimulation with concanavalin A (ConA) and treatment of the cells with interferon α2 (IFNα2) and/or an IFN-derived C-terminal synthetic peptide 2438 (amino acid residues 124–138). Both IFNα2 and the peptide 2438 decreased the level of protein tyrosine phosphorylation in the ConA-stimulated cells. In unstimulated cells, IFNα2 increased, and the peptide 2438 decreased the level of the tyrosine phosphorylation. A possible correlation of these effects with stimulation or cell proliferation is discussed.

【 授权许可】

Unknown