Interaction of a synthetic peptide of the interferon α‐2 C‐terminal part with human blood leukocytes

FEBS Letters

Bulargina, T.V.²  Kirkin, A.F.²  Danilkovitch, A.V.²  Shevalier, A.F.¹  Kharitonenkov, A.I.²  Kolosova, O.V.²  Gusev, M.V.²  Freze, K.V.² 

[1] M.M. Shemyakin Institute of Bioorganic Chemistry, The USSR Academy of Sciences, 117871 Moscow, U.S.S.R.;Moscow State University, Biological Faculty, 119899, Moscow, U.S.S.R.

关键词: IFN α-2;    Synthetic peptide;    Specific binding;    Human;    Lymphocyte;    ConA;    concanavalin A;    IFN;    interferon;    PBMC;    peripheral blood mononuclear cells;    peptide 2438;    a synthetic peptide representing the IFN α-2 amino acid residues 124–138;   

DOI  :  10.1016/0014-5793(91)81387-N

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A biologically active synthetic peptide, 2438, representing the 124–138 amino acid sequence of the human interferon α-2 (IFN α-2) molecule, which is known to possess IFN-like antiproliferative activity, specifically binds to human blood leukocytes. Scatchard plots reveal two different K _fd values, for the ‘low’ and ‘high’ affinity binding. The interaction of the ¹²⁵I-labelled peptide 2438 with the cells is not impaired by human IFN α-2 or cholera toxin.

【 授权许可】

Unknown