Compositional properties of telomeric regions from human chromosomes

FEBS Letters

Aïssani, Brahim¹  De Sario, Albertina¹  Bernardi, Giorgio¹ 

[1] Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France

关键词: Human genome;    Chromosome;    Telomere;    T-band;    Isochore;   

DOI  :  10.1016/0014-5793(91)81375-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have investigated the GC levels of third codon position of genes localized in G- (Giemsa), R- (reverse) and T- (telomeric) bands of human metaphase chromosomes, as well as the hybridization of telomeric probes on fractionated human DNA. The first set of results shows much higher GC levels for genes localized in T-bands than in G- or R-bands (the latter being higher than the former). The second set of data shows that telomeric probes corresponding to T-bands hybridize on the GC-richest family (H3) of isochores, whereas telomeric probes corresponding to R-bands hybridize on GC-rich families H1 and H2; in agreement with these findings, the telomeric repeat common to all chromosomes hybridized on isochore families H1, H2 and H3.

【 授权许可】

Unknown