Pyridoindole stobadine is a potent scavenger of hydroxyl radicals

FEBS Letters

Benes, L.¹  Stefek, M.¹ 

[1] Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska, c., 842 16 Bratislava, Czechoslovakia

关键词: Pyridoindole;    Stobadine;    Hydroxyl radical scavenger;    Deoxyribose assay;    KMBA assay;   

DOI  :  10.1016/0014-5793(91)81444-D

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Stobadine is a potent scavenger of OH^∗ radicals generated chemically in a free solution with k ₂ higher than 10¹⁰ · M⁻¹ s⁻¹ as determined by two independent methods, namely destruction of deoxyribose and oxidation of 2-keto-4-methiolbutyric acid (KMBA). The high efficacy of stobadine to prevent ethylene production from KMBA was observed also in enzymatic (xanthine-xanthine oxidase-driven Fenton) and membrane-bound (NADPH-dependent microsomal electron transfer) sources of OH^∗ radicals.

【 授权许可】

Unknown