Parallel strategies for the synthesis of annulated pyrido[3,4-blindoles via Rh(l)- and Pd(0)-catalyzed cyclotrimerization

TETRAHEDRON LETTERS

卷:59

Article

Saliba, Bianca M.¹  Khanal, Satyam¹  O'Donnell, Michael A.¹  Queenan, Kathryn E.¹  Song, Junho¹  Gentile, Matthew R.¹  Mulcahy, Seann P.¹ 

[1] Providence Coll, Dept Chem & Biochem, 1 Cunningham Sq, Providence, RI 02918 USA

关键词: Pyridoindole;    Cyclotrimerization;    Tandem catalysis;    Multicomponent;   

DOI  :  10.1016/j.tetlet.2018.10.050

来源: Elsevier

【 摘 要 】

Two different pathways for the synthesis of annulated pyrido[3,4-b]indoles are reported using metal-cat-alyzed cyclotrimerization reactions. A stepwise process using Rh(I)-catalysis in the final step of the synthesis and a multicomponent, tandem catalytic approach using Pd(0)-catalysis both lead to complex nitrogen-containing heterocycles in good yields. Substituent effects are investigated for both pathways, demonstrating that the Pd(0)-catalyzed approach is more sensitive to electron-withdrawing groups. (C) 2018 Elsevier Ltd. All rights reserved.

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