Bacterioferritins and ferritins are distantly related in evolution Conservation of ferroxidase‐centre residues

FEBS Letters

Smith, J.M.A.¹  Yewdall, S.J.¹  Harrison, P.M.¹  Andrews, S.C.¹  Guest, J.R.¹ 

[1] Krebs Institute for Biomolecular Research and Department of Molecular Biology and Biotechnology, P.O. Box 594, Firth Court, Western Bank, The University of Sheffield, Sheffield S10 2UH, UK

关键词: Bacterioferritin;    Ferritin;    Iron metabolism;    Profile analysis;    Protein evolution;    Ferroxidase centre;    BFR;    bacterioferritin;    FTN;    Escherichia coli ferritin (gen-165 product);    ISP;    iron-storage protein;    EcBFR;    Escherichia coli BFR;   

DOI  :  10.1016/0014-5793(91)81177-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Iron-storage proteins can be divided into two classes; the bacterioferritins and ferritins. In spite of many apparent structural and functional analogies, no significant amino acid sequence similarity has been detected previously. This report now reveals a distant evolutionary relationship between bacterioferritins and ferritins derived by ‘Profile Analysis’. Optimum alignment of bacterioferritin and ferritin sequences suggests that key residues of the ferroxidase centres of ferritins are conserved in bacterioferritins.

【 授权许可】

Unknown