Cloning of segment polarity gene homologues from the unsegmented brachiopod Terebratulina retusa (Linnaeus)

FEBS Letters

Holland, Peter W.H.¹  Lanfear, Jeremy¹  Williams, Nicola A.¹ 

[1] Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK

关键词: Engrailed;    Homeobox;    Zinc finger gene;    Wingless;    Brachiopod;    Molecular evolution;   

DOI  :  10.1016/0014-5793(91)81286-H

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have used the polymerase chain reaction (PCR) to amplify, clone and sequence homologues of the Drosophila segment polarity genes engrailed (en), cubitus interruptus Dominant (ci^D ) and wingless (wg) from the genome of the brachiopod, Terebratulina retusa (Linnaeus). The deduced translation products of brachiopod en and ci^D share high levels of sequence identity with their Drosophila homologues. The brachiopod wg-related clone is divergent from Drosophila wg, although clearly a member of the wg/Wnt gene family. These results indicate that structural diversity of Drosophila segment polarity genes has been evolutionarily conserved in a divergent, ancient and unsegmented animal phylum.

【 授权许可】

Unknown