Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthases

FEBS Letters

Moncada, Salvador¹  Knowles, Richard G.¹  Salter, Mark¹ 

[1] The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, UK

关键词: Nitric oxide;    Nitric oxide synthase;    Endotoxin;    Rat;    Guinea-pig;    Rabbit;    NO;    nitric oxide;    NOS;    nitric oxide synthase;   

DOI  :  10.1016/0014-5793(91)81123-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The distribution of Ca²⁺-dependent and Ca²⁺-independent nitric oxide synthase (NOS) was studied in rabbits and in control and endotoxin-treated rats and guinea-pigs. There was a widespread localization of NOS which differed for the two forms of the enzyme and which showed marked differences between species. Endotoxin induced the activity of the Ca²⁺-independent NOS in many tissues and also increased the activity of Ca²⁺-dependent NOS in the rat ileum and caecum. These results demonstrate the differential distribution of NOSs in control and endotoxin-treated animals and emphasize the widespread biological role of nitric oxide (NO).

【 授权许可】

Unknown