Heterogeneity in human soluble guanylate cyclase due to alternative splicing

FEBS Letters

Ahlner, Johan¹  Chhajlani, Vijay²  Axelsson, Krister L.¹  Frändberg, Per-Anders¹  Wikberg, Jarl E.S.² 

[1] Department of Pharmacology, Linköping University, S-581 85 Linköping, Sweden;Department of Pharmacology, Umeå University, S-901 87 Umeå, Sweden

关键词: Human guanylate cyclase;    Polymerase chain Reaction;    cDNA;    Alternative splicing;   

DOI  :  10.1016/0014-5793(91)81248-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.

【 授权许可】

Unknown