c‐erb‐A mRNA content and triiodothyronine nuclear receptor binding capacity in rat liver according to vitamin A status

FEBS Letters

Garcin, H.²  Pailler-Rodde, I.²  Higueret, P.²  Begueret, J.¹ 

[1] Laboratoire de Génétique, Av. des Facultés, Université de Bordeaux II, 33405 Talence, France;Laboratoire de Nutrition, ISTAB, Av. des Facultés, Université de Bordeaux I, 33405 Talence, France

关键词: Retinoid;    Vitamin A;    Thyroid hormone;    c-erb-A;    T3-nuclear receptor;   

DOI  :  10.1016/0014-5793(91)80902-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Vitamin A is required for normal growth and development and synergistically acts with thyroid hormones in these processes. Effects of retinol dietary intake (0, 5, 50 U retinol/g food) on the triiodothyronine (T3) nuclear receptor were examined in rat liver. Properties of this receptor have been investigated by an in vitro binding method. The amount of c-erb-A mRNA has been deduced by reverse transcription and amplification methods (PCR). Results show that both retinol deficiency and excess leads to a reduced amount of c-erb-A mRNA and to a decreased T3 binding capacity, suggesting that retinol, or retinoic acid which is its natural metabolite, contributes to the regulation of the T3 nuclear receptor properties.

【 授权许可】

Unknown