Changes in mitochondrial and microsomal rat liver coenzyme Q9, and Q10 content induced by dietary fat and endogenous lipid peroxidation

FEBS Letters

Huertas, J.R.²  Battino, M.³  Mataix, F.J.²  Lenaz, G.¹ 

[1] Dipartimento di Biochimica, Universitá di Bologna, Via Irnerio 48, 40126 Bologna, Italy;Istituto de Nutricion y Tecnologia de Alimentas, Universidad de Granada, Rector Lopez Argueta, S/N,18071 Granada, Spain;Istituto di Biochimica, Università di Ancona, Via Ranieri - Monte D'Ago, 60100 Ancona, Italy

关键词: Coenzyme Q;    HPLC;    Liver mitochondrion and microsome;    Malondialdehyde;    Olive oil;    Corn oil;   

DOI  :  10.1016/0014-5793(91)80022-U

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The influence of different kinds of dietary fat (8%) and of endogenous lipid peroxidation with regard to coenzyme Q₉ (CoQ₉) and coenzyme Q₁₀ (CoQ₁₀) concentrations in mitochondria and microsomes from rat liver has been investigated by means of an HPLC technique. Although the different diet fats used did not produce any effect on microsomes, it was possible to show that each experimental diet differently influenced the mitochondrial levels of CoQ₉ and CoQ₁₀. The highest mitochondrial CoQ content was found in case of a diet supplemented with corn oil. An endogenous oxidative stress induced by adriamycin was able to produce a sharp decrease in mitochondrial CoQ₉ levels in the rats to which corn oil was administered. The results suggest that dietary fat ought to be considered when studies concerning CoQ mitochondrial levels are carried out.

【 授权许可】

Unknown