Identification of a rat liver dipeptidyl aminopeptidase IV with a liver plasma membrane glycoprotein (gp110) A study using dipeptidyl aminopeptidase IV‐deficient rats

FEBS Letters

Watanabe, Yasuhiro¹  Fujimoto, Yukio¹  Iwaki-Egawa, Sachiko¹ 

[1] Department of Clinical Biochemistry, Hokkaido Institute of Pharmaceutical Sciences, Katsuraoka-cho, Otaru-shi, Hokkaido 047-02, Japan

关键词: Dipeptidyl aminopeptidase IV;    110 000 Da Glycoprotein;    Fischer 344 rat;    Wistar rat;   

DOI  :  10.1016/0014-5793(91)80966-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A rat liver plasma membrane glycoprotein, gp110, was compared with dipeptidyl aminopeptidase IV (DAP IV) by using Wistar rats (DAP IV-positive rats) and Fischer 344 rats (DAP IV-negative rats). Fischer rats also lacked gp110 and gp110 of Wistar rats had DAP IV activity. Furthermore, we showed that the C-terminal sequence of gp110 was Ser-Leu-Arg, which was the same as the C-terminal amino acid sequence deduced from the nucleotide sequence of the cDNA of DAP IV. According to these results, we concluded that gp110 was identical with DAP IV.

【 授权许可】

Unknown