Biogenesis of secretory granules Implications arising from the immature secretory granule in the regulated pathway of secretion

FEBS Letters

Tooze, Sharon A.¹ 

[1] EMBL, Meyerhofstrasse 1, 6900 Heidelberg, Germany

关键词: Regulated secretion;    Endocrine;    Immature secretory granule;    Maturation;    Clathrin adaptins;    GTP-binding proteins;   

DOI  :  10.1016/0014-5793(91)80805-D

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In endocrine cells the regulated secretion of hormones, peptides, enzymes and neurotransmitters into the external medium occurs when mature secretory granules fuse with the plasma membrane. Secretory granules form at the trans-Golgi network (TGN) by envelopment of the dense-core aggregate of regulated secretory proteins by a specific membrane. The secretory granules initially formed at the TGN, referred to here as immature secretory granules, are morphologically and biochemically distinct from mature secretory granules. The functional similarities and differences between the immature secretory granule and the mature secretory granule, and the events involved in the maturation of the secretory granules are briefly discussed.

【 授权许可】

Unknown