Apolipoprotein B gene expression in rat intestine The effect of dietary fiber

FEBS Letters

Felgines, Catherine¹  Bayle, Dominique¹  Mazur, Andrzej¹  Gueux, Elyett¹  Rayssiguier, Yves¹  Rémésy, Christian¹  Cardot, Philippe¹  Nassir, Fatiha¹ 

[1] Laboratoire des Maladies Métaboliques, Institut National de la Recherche Agronomique, Theix, 63122 Ceyrat, France

关键词: Apolipoprotein B;    mRNA level;    Dietary fiber;    Intestine;    Bile salt;   

DOI  :  10.1016/0014-5793(91)80762-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of the dietary fiber on apo B mRNA level was studied in the intestine of rats that were fed either fiber-free or high-fiber (30% sugar-beet fiber) low-fat diets for 3 weeks. The fiber diet studied does not affect jejunal apo B mRNA levels but decreases the level of ileal apo B mRNA. In the rat cecum, in both fiber-free and fiber groups, we failed to detect the apo B mRNA. The test fiber diet feeding markedly increased fecal bile salt and cholesterol excretions. We suggest that dietary fiber can modify apo B expression in the intestine. The increased fecal bile salt excretion might be involved in such a modification.

【 授权许可】

Unknown