The effect of F0 inhibitors on the Vibrio alginolyticus membrane ATPase

FEBS Letters

Dmitriev, O.Yu.²  Krasnoselskaya, I.A.²  Papa, S.¹  Capozza, G.¹  Skulachev, V.P.² 

[1] Institute of Medical Biochemistry and Chemistry, University of Bari, Bari, Italy;A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, 119899 Moscow, USSR

关键词: Bacterial F0F1-ATPase;    Na+(H+)-ATPase;    Vibrio alginolyticus;    DCCD;    N;    N′-dicyclohexylcarbodilmide;   

DOI  :  10.1016/0014-5793(91)80310-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The inhibition of membrane ATPase from the marine alkalotolerant bacterium Vibrio alginolyticus by DCCD, triphenyltin and venturicidin was studied. DCCD proved to be an irreversible inhibitor, while venturicidin and triphenyltin produced a reversible inhibitory effect. The DCCD-binding proteolipid was identified in the membrane preparations. The effect of the inhibitors on ATPase activity and ATP-dependent Na⁺-transport in V. alginolyticus subcellular vesicles is discussed.

【 授权许可】

Unknown