Intramitochondrial formation of oxidized glutathione during the oxidation of benzylamine by monoamine oxidase

FEBS Letters

Werner, Peter¹  Cohen, Gerald¹ 

[1] Department of Neurology and Fishberg Center for Neurobiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA

关键词: Mitochondrion;    Monoamine oxidase;    Oxidative stress;    GSSG;    H2O2;    Deprenyl;   

DOI  :  10.1016/0014-5793(91)80200-M

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oxidation of benzylamine by MAO results in an accumulation of GSSG in mouse liver mitochondria. Formation of GSSG is prevented by deprenyl, an inhibitor of MAO-B, but not by catalase. GSSG accumulation also occurs with dopamine as substrate. Oxidation of monoamines by mitochondrial MAO represents a potential oxidant stress for mitochondria.

【 授权许可】

Unknown