期刊论文详细信息
FEBS Letters | |
Intramitochondrial formation of oxidized glutathione during the oxidation of benzylamine by monoamine oxidase | |
Werner, Peter1  Cohen, Gerald1  | |
[1] Department of Neurology and Fishberg Center for Neurobiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA | |
关键词: Mitochondrion; Monoamine oxidase; Oxidative stress; GSSG; H2O2; Deprenyl; | |
DOI : 10.1016/0014-5793(91)80200-M | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Oxidation of benzylamine by MAO results in an accumulation of GSSG in mouse liver mitochondria. Formation of GSSG is prevented by deprenyl, an inhibitor of MAO-B, but not by catalase. GSSG accumulation also occurs with dopamine as substrate. Oxidation of monoamines by mitochondrial MAO represents a potential oxidant stress for mitochondria.
【 授权许可】
Unknown
【 预 览 】
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