Nucleotide sequence of the Yersinia pestis gene encoding F1 antigen and the primary structure of the protein

FEBS Letters

Denesyuk, A.I.³  Rubtsov, K.S.¹  Zav'yalov, V.P.³  Dalvadyanz, S.M.⁴  Nazimov, I.V.¹  Smirnov, O.Yu.³  Abramov, V.M.³  Karlishev, A.V.²  Volkovoy, K.I.²  Galyov, E.E.³ 

[1] Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Miklukho-Maklay Street 16110, Moscow, USSR;All-Union Research Institute of Applied Microbiology, USSR Ministry of Medical Industry, 142279 Obolensk, Moscow Region, USSR;Institute of Immunology, USSR Ministry of Medical Industry, 142380 Lyubuchany, Moscow Region, USSR;All-Union Antiplague Institute ‘Microb’, USSR Ministry of Health, Universitetskaya Street 46, 410071 Saratov, USSR

关键词: Capsular antigen;    Nucleotide sequence;    Signal sequence;    Antigenic determinant;    Yersinia pestis;   

DOI  :  10.1016/0014-5793(90)80852-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The plasmid-located gene cafl encoding the capsular antigen fraction 1 (F1) of Yersinia pestis was cloned and sequenced. The gene codes for a 170 amino acid peptide with a deduced M _r of 17.6 kDa. The signal peptide sequence was highly homologous to the E. coli consensus signal sequence. The F1 was assumed to have β-sheet structure for the most part. The region located between amino acids 100 and 150 was suggested to contain putative antigenic determinants and to stimulate T cells.

【 授权许可】

Unknown