Slipping pumps or proton leaks in oxidative phosphorylation

FEBS Letters

Unami, Akira¹  Shinohara, Yasuo¹  Terada, Hiroshi¹  van Dam, Karel¹  Yoshida, Kenji¹ 

[1] Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi-1, Tokushima 770, Japan

关键词: Oxidative phosphorylation;    Uncoupling;    Mitochondria;    Local anesthetic;    Proton pump;   

DOI  :  10.1016/0014-5793(90)80826-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence is presented to show that the local anesthetic bupivacaine causes slip in the mitochondrial proton pump cytochrome c oxidase.

【 授权许可】

Unknown