FEBS Letters | |
Activation of red cell Ca2+ ‐activated K+ channel by Ca2+ involves a temperature‐dependent step | |
Peterajová, Elena1  Varečka, Ĺudovít1  | |
[1] Mental Health Research Center of the Medical Bionics Institute, Psychiatric Hospital, 90218-Pezinok, Czechoslovakia | |
关键词: Red cell; Vanadate; Propronolol; Ca2+-activated K+ channel; | |
DOI : 10.1016/0014-5793(90)80534-P | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We found that vanadate-induced 45Ca2+ uptake by red cells is maximal at 25°C. At this temperature, the Cai-induced increase of the K+ permeability (the Gardos effect) shows a lag (up to 8 min) which is not observed at 37°C. This cannot be explained by the lack of availability of Ca2+ for the Ca2+-activated K+ channel, and suggests that its activation by Ca2+ is mediated by a temperature-dependent mechanism which remains unknown so far. The lag is not observed when the Gárdos effect was initiated by propranolol. This shows that the putative temperature-dependent step is different from chloride transport.
【 授权许可】
Unknown
【 预 览 】
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