FEBS Letters | |
Partial hepatectomy and mediators of inflammation decrease the expression of liver α2‐HS glycoprotein gene in rats | |
Julen, N.1  Lemetayer, J.1  Davrinche, C.3  Lebreton, J.P.1  Hiron, M.1  Djelassi, N.1  Arnaud, P.2  Daveau, M.1  | |
[1] INSERM Unité 78, BP 73, 76233 Bois-Guillaume Cedex, France;Laboratory of Molecular Genetics, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA;INSERM Unité 100, CHU Purpan, 31052 Toulouse Cedex, France | |
关键词: Acute phase; Liver protein synthesis; Cytokine; mRNA; AHSG; α2-HS glycoprotein; ORM; α1-acid glycoprotein; TNF; tumor necrosis factor; | |
DOI : 10.1016/0014-5793(90)81055-S | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Liver mRNA levels of two acute phase reactant (APR) proteins, α2-HS glycoprotein (a major negative APR) and α1,-acid glycoprotein (a major positive APR) were measured in male rats at different times after the administration of turpentine, of tumor necrosis factor, or following partial hepatectomy. In every case, a marked decrease in mRNA levels of α2HS glycoprotein was observed which reached a maximum at 24 h. A concomitant increase of α1,-acid glycoprotein mRNA levels was observed under the same conditions. These results indicate that the decreased levels of α2-HS glycoprotein induced by the acute-phase response following inflammatory mediators and partial hepatectomy are due to a down-regulation of the gene expression of this protein in rat liver.
【 授权许可】
Unknown
【 预 览 】
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