Partial hepatectomy and mediators of inflammation decrease the expression of liver α2‐HS glycoprotein gene in rats

FEBS Letters

Julen, N.¹  Lemetayer, J.¹  Davrinche, C.³  Lebreton, J.P.¹  Hiron, M.¹  Djelassi, N.¹  Arnaud, P.²  Daveau, M.¹ 

[1] INSERM Unité 78, BP 73, 76233 Bois-Guillaume Cedex, France;Laboratory of Molecular Genetics, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA;INSERM Unité 100, CHU Purpan, 31052 Toulouse Cedex, France

关键词: Acute phase;    Liver protein synthesis;    Cytokine;    mRNA;    AHSG;    α2-HS glycoprotein;    ORM;    α1-acid glycoprotein;    TNF;    tumor necrosis factor;   

DOI  :  10.1016/0014-5793(90)81055-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Liver mRNA levels of two acute phase reactant (APR) proteins, α₂-HS glycoprotein (a major negative APR) and α₁,-acid glycoprotein (a major positive APR) were measured in male rats at different times after the administration of turpentine, of tumor necrosis factor, or following partial hepatectomy. In every case, a marked decrease in mRNA levels of α₂HS glycoprotein was observed which reached a maximum at 24 h. A concomitant increase of α₁,-acid glycoprotein mRNA levels was observed under the same conditions. These results indicate that the decreased levels of α₂-HS glycoprotein induced by the acute-phase response following inflammatory mediators and partial hepatectomy are due to a down-regulation of the gene expression of this protein in rat liver.

【 授权许可】

Unknown