The biological activity of retinoids in melanoma cells

FEBS Letters

Latham, Julie A.E.¹  Daly, Ann K.¹  Redfern, Christopher F.F.¹  Todd, Carole¹ 

[1] Medical Molecular Biology Group, Department of Dermatology, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK

关键词: Retinoic acid;    Retinoic acid receptor;    Melanoma;    RAR-β;    3;    4-Didehydroretinoic acid;   

DOI  :  10.1016/0014-5793(90)81041-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression of mRNA for retinoic acid receptor beta (RAR-β was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-β was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-β but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-α and RAR-γ was unaffected by retinoic acid.

【 授权许可】

Unknown