Synthetic polymeric sialoside inhibitors of influenza virus receptor‐binding activity

FEBS Letters

Matrosovich, M.N.¹  Marinina, V.P.¹  Bovin, N.V.²  Byramova, N.E.²  Mochalova, L.V.¹ 

[1] Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, 142 782 Moscow Region, USSR;Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, 117871 Moscow, Miklukho-Maklaya 16/10, USSR

关键词: Influenza virus;    Virus attachment inhibitor;    Inhibitor of hemagglutination;    Sialic acid;    Fetuin;    Antiviral drug;    FBI;    fetuin-binding inhibition;    HA;    hemagglutinin;    HAI;    hemagglutination inhibition;    HRP;    horseradish peroxidase;    Neu5Ac;    5-N-acetylneuraminic acid;    RBS;    receptor-binding site;    SAα2;    6Lac;    α2;    6 sialyllactose;   

DOI  :  10.1016/0014-5793(90)80486-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Anomeric aminobenzylglycosides of Neu5Ac were coupled with the polyacrylate carrier and a number of synthetic polyvalent sialosides obtained were investigated as inhibitors of influenza virus attachment. The inhibitory activity of polymeric sialosides is highly dependent upon the Neu5Ac residue content and the nature of the carrier. The polyacrylic acid based polymer bearing 10 mol% of Neu5Ac is 3 orders of magnitude more potent inhibitor than the corresponding monovalent benzylsialoside and considerably more active than fetuin.

【 授权许可】

Unknown