Influenza A virus induced bacterial otitis media is independent of virus tropism for α2,6-linked sialic acid

Virology Journal

Odilia L Wijburg³  Dimitri A Diavatopoulos²  Patrick C Reading¹  Jean Payne⁴  Marrit N Habets²  Kirsty R Short³ 

[1] WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC, 3051, Australia;Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud University Medical Centre, Nijmegen, The Netherlands;Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VIC, 3010, Australia;Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia

关键词: Influenza virus;    Sialic acid;    Viral-bacterial co-infection;    Otitis media;   

Others  :  1150621
DOI  :  10.1186/1743-422X-10-128

 received in 2012-11-30, accepted in 2013-04-15,  发布年份 2013

【 摘 要 】

Background

Otitis media (OM) affects ≥80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear.

Findings

Here, we assess if the increased replication of IAV strains such as Udorn/72 in the middle ear is dependent upon the binding of the viral HA to α2,6-linked sialic acid. Using murine and in vitro models, the present study shows that recognition of α2,6-linked sialic acid was not required to facilitate bacterial OM.

Conclusions

Taken together, these data suggest that other features of the HA mediate bacterial OM.

【 授权许可】

   
2013 Short et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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