Spin‐spin relaxation of the phosphodiester resonance in the 31P NMR spectrum of human brain

FEBS Letters

Allis, Jonathan L.¹  Kilby, Peter M.¹  Radda, George K.¹ 

[1] Medical Research Council Biochemical and Clinical Magnetic Resonance Unit, Oxford University, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK

关键词: Nuclear magnetic resonance;    Spin-spin relaxation;    Human brain;   

DOI  :  10.1016/0014-5793(90)80474-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The phosphodiester peak in ³¹P nuclear magnetic resonance spectra of human brain in vivo is often the most prominent feature of the spectrum. We have demonstrated that this resonance exhibits bi-exponential spin-spin relaxation, giving relaxation times of 2 and 10 ms. We interpret this in terms of the two components which make up the peak, bilayer lipids and the small cytosolic phosphates glycerophosphoethanolamine and glycerophosphocholine. Using the relaxation times and the relative peak heights of the two components we have also been able to quantitate the concentration of the bilayer lipids as 20–40 times that of ATP.

【 授权许可】

Unknown