Biosynthesis of cyclic 2,3‐diphosphoglycerate

FEBS Letters

Hensel, Reinhard¹  Lehmacher, Anselm¹  Vogt, Anne-Barbara¹ 

[1] Max-Planck-Institut für Biochemie, Am Klopferspitz, D-8033 Martinsried, FRG

关键词: cyclic 2;    3-diphosphoglycerate;    2-Phosphoglycerate kinase;    cyclic 2;    3-diphosphoglycerate synthetase;    Methanogen;    cDPG;    cyclic 2;    3-diphosphoglycerate;    cDPGS;    cyclic 2;    3-diphosphoglycerate synthetase;    2;    3-DPG;    2;    3-diphosphoglycerate;    2-PG;    2-phosphoglycerate;    2PGK;    2-phosphoglycerate kinase;   

DOI  :  10.1016/0014-5793(90)80456-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Starting from 2-phosphoglycerate the biosynthesis of cDPG comprises two steps: (i) the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate and (ii) the intramolecular cyclization to cyclic 2,3-diphosphoglycerate. The involved enzymes, 2-phosphoglycerate kinase and cyclic 2,3diphosphoglycerate synthetase, were purified form Methanothermus fervidus. Their molecular and catalytic properties were characterized.

【 授权许可】

Unknown