Analysis of the effect of bezafibrate on the oxygen dissociation curve of human hemoglobin

FEBS Letters

Wootton, Raymond¹ 

[1] Department of Biochemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, England

关键词: 2;    3-Diphosphoglycerate;    Bezafibrate;    Oxygen dissociation curve;    Hemoglobin;    Right-shift;    DPG;    2;    3-diphosphoglycerate;    IHP;    myo-inositol hexaphosphate;    bezafibrate;    2-[4-(2-p-chlorobenzamidoethyl)phenoxyl]-2-methylpropionate;   

DOI  :  10.1016/0014-5793(84)80485-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Analysis of the effects of a range of concentrations of the antihyperlipoproteinemia drug, bezafibrate, on the oxygen dissociation curve of dilute hemoglobin solutions indicates a 4:1 binding stoichiometry with a site binding constant of 434 mol^t-1 for deoxyhemoglobin. Analysis of the combined effects of a range of bezafibrate and 2,3-diphosphoglycerate (DPG) concentrations indicates that 2 of the 4 bezafibrate sites are in the vicinity of the DPG binding site, and competitive with DPG binding, and 2 of the sites are remote from the DPG binding site.

【 授权许可】

Unknown