Revised structure of the peptide lactone antibiotic, TL‐119 and/or A‐3302‐B

FEBS Letters

Waki, Michinori²  Kitajima, Yasuo²  Izumiya, Nobuo²  Ueno, Tamio³  Shoji, Jun'ichi¹ 

[1] Shionogi Research Laboratories, Shionogi and Co. Ltd., Fukushima-ku, Osaka 553, Japan;Laboratory of Biochemistry, Faculty of Science, Kyushu University 33, Higashi-ku, Fukuoka 812, Japan;Pesticide Research Institute, College of Agriculture, Kyoto University, Sakyo-ku, Kyoto, 606, Japan

关键词: Cyclic peptide;    Peptide synthesis;    Antibacterial activity;    Structure confirmation;    Abbreviations used are according to IUPAC-IUB Commissions (1984) Eur. J. Biochem. 138;    9-37. Other abbreviations: DCC;    dicyclohexylcarbodiimide;    HOBt;    1-hydroxybenzotriazole;    HOSu;    N-hydroxysuccinimide;    HPTLC;    high-performance thin layer chromatography;   

DOI  :  10.1016/0014-5793(90)81253-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The peptide lactone antibiotic TL-119 and/or A-3302-B was chemically synthesized in order to confirm the proposed structure. The synthetic compound was different from both natural TL-119 and A-3302-B in their physicochemical properties and in biological activity. Re-examination of the configuration of the constituent amino acid residues in natural TL-119 and/or A-3302-B indicated that natural TL-119 and A-3302-B contains D-aThr instead of the original L-Thr. We tentatively propose a revised structure for TL-119 and/or A-3302-B.

【 授权许可】

Unknown