Structure and developmental expression of the Dα2 gene encoding a novel nicotinic acetylcholine receptor protein of Drosophila melanogaster

FEBS Letters

Baumann, Arnd¹  Jonas, Petra¹  Merz, Barbara¹  Gundelfinger, Eckart D¹ 

[1] ZMNH, Zentrum für Molekulare Neurobiologie, Universität Hamburg, Martinistr. 52, D-2000 Hamburg 20, FRG

关键词: Nicotinic acetylcholine receptor;    Nervous system;    Gene structure;    Development;    Evolution;    Drosophila melanogaster;    nAChR;    nicotinic acetylcholine receptor;    Dα2;    Drosophila α-like subunit 2;    ALS;    α-like subunit;    ARD;    nAChR protein of Drosophila;   

DOI  :  10.1016/0014-5793(90)81170-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Nicotinic acetylcholine receptors (nAChRs) represent a heterogeneous group of excitatory neurotransmitter receptors in the insect brain. We have characterized the Dα2 gene of Drosophila melanogaster, a new member of the nAChR gene family. The protein coding region is interrupted by six introns. The positions of three of these introns are shared with all other nAChR genes. The deduced Dα2 protein shows the structural features of ligand-binding nAChR α-subunits. Cytogenetically, the Dα2 gene maps at position 96A of the 3rd chromosome, close to the ALS gene which also encodes an α-like nAChR subunit. Dα2 transcripts are predominantly expressed in late embryos and in fly heads.

【 授权许可】

Unknown