Involvement of external calcium in the release of arachidonic acid by mouse peritoneal macrophages

FEBS Letters

Balsinde, Jesús¹  Fernández, Belén² 

[1] Centro de Investigaciones Biológicas (CSIC), Madrid, Spain;Centro de Investigación, Hospital 12 de Octubre, Madrid, Spain

关键词: Arachidonic acid;    Calcium influx;    Phospholipase A2;    Mouse macrophage;    AA;    arachidonic acid;    PMA;    phorbol 12-myristate;    13-acetate;   

DOI  :  10.1016/0014-5793(90)80984-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The present investigation was undertaken to study the potential role of extracellular calcium on the release of arachidonic acid from mouse peritoneal macrophages. Both in phorbol ester-treated and in Ca²⁺-depleted cells, a rapid release of arachidonic acid was seen in direct response to added Ca²⁺. The response was directly dependent on the extracellular Ca²⁺concentration, with a Ca²⁺ threshold of 100 nM. These results support the notion that arachidonic acid release in macrophages is functionally coupled to influx of external calcium.

【 授权许可】

Unknown