Exercise training increases glucose transporter protein GLUT‐4 in skeletal muscle of obese Zucker (fa/fa) rats

FEBS Letters

Reed, Michael J.¹  Sherman, William M.¹  Friedman, Jacob E.²  Eiton, Charles W.²  Dohm, G.Lynis² 

[1] School of HPER, The Ohio State University, 337 17th Ave, Columbus, OH 43210-1284, USA;Department of Biochemistry, School of Medicine, East Carolina University, Greenville, NC 27858-4354, USA

关键词: Insulin resistance;    Skeletal muscle;    Obesity;    Exercise;    Glucose transporter;   

DOI  :  10.1016/0014-5793(90)80960-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The present study examined the level of GLUT-4 glucose transporter protein in gastrocnemius muscles of 36 week old genetically obese Zucker (fa/fa) rats and their lean (Fa/-) littermates, and in obese Zucker rats following 18 or 30 weeks of treadmill exercise training. Despite skeletal muscle insulin resistance, the level of GLUT-4 glucose transporter protein was similar in lean and obese Zucker rats. In contrast, exercise training increased GLUT-4 protein levels by 1.7 and 2.3 fold above sedentary obese rats. These findings suggest endurance training stimulates expression of skeletal muscle GLUT-4 protein which may be responsible for the previously observed increase in insulin sensitivity with training.

【 授权许可】

Unknown