Further studies of a new vitamin E analogue more active than α‐tocopherol in the rat curative myopathy bioassay

FEBS Letters

Hughes, L.²  Burton, G.W.²  Foster, D.O.¹  Ingold, K.U.² 

[1] Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ont. K1A OR6, Canada;Divisions of Chemistry, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ont. K1A OR6, Canada

关键词: Vitamin E analogue;    Rat curative myopathy assay;    Peroxyl radical;    Antioxidant;   

DOI  :  10.1016/0014-5793(90)80288-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The bioactivities of the acetates of 2R,4'R,8'R- and 25,4'R,8'R-2,4,6,7-tetramethyl-2-(4',8',12'-trimethyltridecyl)-5-hydroxy-3,4-dihydrobenzofuran (RRR- and SRR-1-Ac) have been measured in the rat curative myopathy bioassay and compared with the RRR and SRR stereoisomers of α-tocopheryl acetate (RRR- and SRR-2-Ac). Each stereoisomer of 1 is only slightly more active than the corresponding stereoisomer of 2(RRR-1-Ac/RRR-2-Ac = 110; SRR-1-Ac/SRR-2-Ac = 1.16). This finding contrasts with our earlier finding [(1986) FEBS Lett. 205, 117 120], confirmed in the present study, that all-rac-1-Ac is 1.5-1.9 as active as all-rac-2-Ac. We suggest that the stereochemistry (S vs R) at the 4' and 8' tail carbons is of less biological importance in 1 than in 2.

【 授权许可】

Unknown