Desferrioxamine as a lipid chain‐breaking antioxidant in sickle erythrocyte membranes

FEBS Letters

Rice-Evans, Catherine¹  Davies, Michael²  Hartley, Andrew¹ 

[1] Department of Biochemistry and Chemistry, Royal Free Hospital School of Medicine, University of London, Rowland Hill Street, London NW3 2PF UK;Department of Chemistry, University of York, Heslington, York Y01 5DD, UK

关键词: Desferrioxamine;    Iron;    Antioxidant;    Sickle erythrocyte membrane;    Electron spin resonance spectroscopy;   

DOI  :  10.1016/0014-5793(90)80786-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The mechanism of action of desferrioxamine in the inhibition of the catalysis of iron-induced oxidative damage has been ascribed to its ability to chelate available ferric ion (K _b = 10³¹). However, recent work has proposed that the trihydroxamate moiety of desferrioxamine can also be involved in electron transfer reactions involving the Superoxide radical, peroxidase/hydrogen peroxide mixtures and ferryl myoglobin radicals. In this study we report evidence for the ability of desferrioxamine to inhibit peroxidative damage to pathological membranes with which non-haem iron is associated through a mechanism of action as a lipid chain breaking antioxidant, independently of its iron chelating properties.

【 授权许可】

Unknown