期刊论文详细信息
FEBS Letters | |
Nucleotide sequence determination of chicken glucagon precursor cDNA | |
Takada, Tatsuyuki1  Nata, Koji2  Yamamoto, Hiroshi2  Okamoto, Hiroshi2  Hasegawa, Shin1  Terazono, Kimio2  | |
[1] Department of Animal Nutrition, Faculty of Agriculture, Kobe University, Kobe 657, Hyogo, Japan;Department of Biochemistry, Tohoku University School of Medicine, Sendai 980, Miyagi, Japan | |
关键词: Preproglucagon; Glucagon; Glucagon-like peptide; mRNA; cDNA cloning; Gallus gallus domesticus; | |
DOI : 10.1016/0014-5793(90)80779-I | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
cDNA clones coding for glucagon were isolated from a chicken pancreas cDNA library, and the nucleotide and amino acid sequences were determined. The amino acid sequence of chicken glucagon was HSQGTFTSDYSKYLDSRRAQDFVQWLMST, which was contained in the 151-amino acid long precursor, being preceded by a signal sequence and an amino-terminal peptide (NH2-peptide) and followed by an intervening peptide and a glucagon-like peptide I (GLP-I). Chicken preproglucagon, however, lacked GLP-II and intervening peptide II which have been shown to be contained in mammalian glucagon precursors.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020293380ZK.pdf | 434KB | download |