Modulation ofinterleukin‐1β production by cyclic AMP in human monocytes

FEBS Letters

Hurme, Mikko¹ 

[1] Department of Bacteriology and Immunology, University of Helsinki, Haartmaninkatu 3,00290, Helsinki, Finland

关键词: Interieukin-1;    AMP;    3';    5'-cyclic;    Monocyte;    (Human);   

DOI  :  10.1016/0014-5793(90)80699-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Elevation of cAMP has been considered to be an important downregulative signal in the production ofinterieukin-1(IL-1). This study demonstrates that this phenomenon is dependent on the signal used to activate the IL-1 production. The IL-1β production of lipopolysaccharide activated human monocytes was readily inhibited by dibutyryl cAMP. This took place without a significant change in the steady-state levels of IL-1β mRNA. By contrast, in PMA activated monocytes 100 μM dibutyryl cAMP increased in IL-1β production ca. 4-fold. The steady-statelevels of IL-1β mRNA were also simultaneously increased.

【 授权许可】

Unknown