A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region

FEBS Letters

Marynen, P.¹  Van den Berghe, H.¹  Devriendt, K.¹  Cassiman, J.J.¹ 

[1] Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium

关键词: Proteinase inhibitor;    Macroglobulin;    α;   

DOI  :  10.1016/0014-5793(90)80226-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Genomic clones containing the exons coding for the bait domain of human pregnancy zone protein and α₂ macroglobulin were isolated and fragments containing the bait exons were sequenced. It is shown that the bait domains of both α₂ macroglobulin and pregnancy zone protein are encoded by two exons, with conserved exon/intron boundaries. A genetic polymorphism showing either a Met or a Val residue as the sixth amino acid of the pregnancy zone protein bait domain was detected with the rare Met allele showing a gene frequency of 0.065.

【 授权许可】

Unknown