Rapid up‐ and down‐regulation of hexokinase II in rat skeletal muscle in response to altered contractile activity

FEBS Letters

Weber, Franz E.¹  Pette, Dirk¹ 

[1] Fakultät für Biologie, Universität Konstanz, D-7750 Konstanz, FRG

关键词: Contractile activity;    Hexokinase II;    Protein synthesis;    Fast-twitch muscle;    (Rat);   

DOI  :  10.1016/0014-5793(90)80574-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An up to 14-fold increase in total hexokinase activity induced by low-frequency stimulation in rat fast-twitch muscle was followed by a rapid decay in enzyme activity after cessation of stimulation. In vivo labeling revealed that these alterations were related to rapid changes in [³⁵S]methionine incorporation into hexokinase II. A recovery period of 15 h after cessation of stimulation was sufficient to normalize the approximately 30-fold elevated [³⁵S]methionine incorporation.

【 授权许可】

Unknown