Crystallization of proteins under microgravity

FEBS Letters

Betzel, Christian⁵  Plaas-Link, Andreas¹  Düvel, Martina²  Schulz, Georg E.⁶  Weber, Gabriela⁸  Erdmann, Volker A.⁴  Müller, Christoph W.⁶  Saenger, Wolfram²  Dauter, Zbyszek⁵  Hinrichs, Winfried²  Liesum, Alexander⁷  Wittmann, Heinz G.³  Yonath, Ada⁸  Lippmann, Corinna⁴  Müller-Fahrnow, Anke²  Hilgenfeld, Rolf⁷  Hoven, Julia⁵  Stegen, Karin¹  Wilson, Keith⁵ 

[1] Intospace, Prinzenstr. 17, D-3000 Hannover 1, FRG;Institut für Kristallographie. FU, Takustr. 6, D-1000 Berlin 33, Germany;Max-Planck-Institut für molekulare Genetik, Ihnestr. 63-73, D-1000 Berlin 33, Germany;Institut für Biochemie, Thielallee 63, D-1000 Berlin 33, Germany;EMBL c/o DESY, Notkestr. 85, D-2000 Hamburg 52, FRG;Universität Freiburg, Albertstr. 21, D-7800 Freiburg, FRG;Hoechst AG, P.O.B. 800320, D-6230 Frankfurt 80, FRG;Max-Planck-Forschungsgruppe für strukturelle Molekularbiologie c/o DESY, Notkestr. 85, D-2000 Hamburg 52, FRG

关键词: Protein crystallization;    Microgravity;   

DOI  :  10.1016/0014-5793(89)81526-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

For the crystallization of proteins under microgravity conditions, a Chinese re-entry system was used, in which 101 experiments of 25 different biological macromolecules were accommodated. From the results obtained we conclude that under microgravity conditions crystal growth can only be expected under those crystallization conditions which also permit crystal growthon earth. A number of space-grown crystals were larger in size and of a better quality in their ability to diffract X-rays than the corresponding ground control crystals grown at the Chinese launch site. However, the space-grown crystals have not reached the X-ray diffraction quality of the crystals obtained under optimal conditions in the home laboratories.

【 授权许可】

Unknown