Antibacterial and antimalarial properties of peptides that are cecropin‐melittin hybrids

FEBS Letters

Merrifield, R.B.¹  Wade, D.¹  Boman, H.G.³  Wåhlin, B.²  Boman, I.A.³ 

[1] Rockefeller University, New York, NY 10021-6399, USA;Immunology, University of Stockholm, S-10691 Stockholm, Sweden;Departments of Microbiology, University of Stockholm, S-10691 Stockholm, Sweden

关键词: Cecropin A;    Melittin;    (Staphylococcus aureus;    Plasmodium falciparium);   

DOI  :  10.1016/0014-5793(89)81505-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Solid phase synthesis was used to produce 5 hybrid peptides containing sequences from the antibacterial peptide, cecropin A, and from the bee venom toxin, melittin. Four of these chimeric peptides showed good antibacterial activity against representative Gram-negative and Gram-positive bacterial species. The best hybrid, cecropin A(1–13)-melittin(1–13) was 100-fold more active than cecropin A against Staphylococcus aureus. It was also a 10-fold better antimalarial agent than cecropin B or magainin 2. Sheep red cells were lysed by melittin at low concentrations, but not by the hybrid molecules, even at 50 times higher concentrations.

【 授权许可】

Unknown