Human Na+, K+ ‐ATPase genes

FEBS Letters

Petrukhin, K.E.¹  Bessarab, D.A.¹  Sverdlov, E.D.¹  Modyanov, N.N.¹  Monastyrskaya, G.S.¹  Orlova, M.Yu.¹  Ushkaryov, Yu.A.¹  Nikiforova, N.N.¹  Broude, N.E.¹ 

[1] Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, 117871 Moscow, USSR

关键词: ATPase;    Na+;    K+-;    β-Subunit;    Family of gene;    Exon/intron structure;    Pseudogene sequence;   

DOI  :  10.1016/0014-5793(89)81591-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The existence of a chromosome gene family containing at least one gene and one pseudogene was shown for the Na⁺,K⁺-ATPase β-subunit. A partial structure of the βI-gene was determined, the coding part of which was completely homologous to cDNA of the Na⁺ K⁺-ATPase βI-subunit from HeLa cells [8]. The region encoding the putative protein transmembrane domain was shown to be bordered by two introns. The structure of a pseudogene (βψ) was determined. This pseudogene is processed and contains multiple stop codons. Its homology to the βI-subunit cDNA from HeLa cells is about 88%.

【 授权许可】

Unknown