Thyroid hormone stimulates expression of 6‐phosphofructo‐2‐kinase in rat liver

FEBS Letters

Rousseau, Guy G.¹  Hue, Louis¹  Crepin, Karine M.¹  van den Hove, Marie-France¹  Wall, Stephen R.¹ 

[1] Hormone and Metabolic Research Unit, International Institute of Cellular and Molecular Pathology and Louvain University Medical School, B-1200 Brussels, Belgium

关键词: Phosphofructo-2-kinase;    6-;    Fructose 2;    6-bisphosphate;    Thyroid hormone;    mRNA;    (Rat liver;    Rat heart);    PFK-2;    6-phosphofructo-2-kinase;    T3;    triiodothyronine;    T4;    thyroxine;   

DOI  :  10.1016/0014-5793(89)81536-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The activity of liver 6-phosphofructo-2-kinase (PFK-2), the enzyme that catalyses the synthesis of fructose 2,6-bisphosphate, was markedly decreased in hypothyroid rats and partially restored after 3 days of treatment with triiodothyronine. The changes in PFK-2 activity were accompanied by parallel changes in enzyme content measured by immunotitration and in PFK-2 mRNA determined by dot blot and Northern blot hybridization with cDNA probes. It is concluded that thyroid hormone stimulates liver PFK-2 gene expression by a pre-translational mechanism.

【 授权许可】

Unknown