Cloning, sequence analysis and chromosome localization of a Drosophila muscarinic acetylcholine receptor

FEBS Letters

FitzGerald, Michael G.¹  McCombie, W.Richard¹  Arakawa, Shoji¹  Fraser, Claire M.¹  Urquhart, Deborah A.²  Onai, Takeshi¹  Gocayne, Jeannine D.¹  Hall, Linda M.²  Venter, J.Craig¹ 

[1] Section of Receptor Biochemistry and Molecular Biology, Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA;Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA

关键词: Receptor evolution;    Sequence homology;    Signal sequence;    cDNA;    DNA sequence analysis;    automated;    Receptor supergene family;   

DOI  :  10.1016/0014-5793(89)81095-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two cDNA clones (3.7 kb and 4.8 kb) encoding a Drosophila muscarinic acetylcholine receptor were isolated from a Drosophila head cDNA library and characterized by automated DNA sequence analysis. The Drosophila muscarinic receptor contains 788 amino acids with a calculated M _r of 84 807 and displays greater than 60% homology with mammalian muscarinic receptors. The muscarinic receptor maps to the tip of the right arm of the second chromosome of the Drosophila genome.

【 授权许可】

Unknown