Identification of the ferroxidase centre in ferritin

FEBS Letters

Harrison, Pauline M.²  Levi, Sonia¹  Artymiuk, Peter J.²  Luzzago, Alessandra³  Treffry, Amyra²  Yewdall, Stephen J.²  Cesareni, Gianne⁴  Lawson, David M.²  Arosio, Paolo¹ 

[1] Department of Biomedical Science and Technology, University of Milan, Ospedale San Raffaele, via Olgettina 60, I-20132 Milano, Italy;The Krebs Institute, Department of Molecular Biology and Biotechnology, The University, Sheffield S10 2TN, England;EMBL, Meyerhofstrasse 1, 6900 Heidelberg, FRG;Dipartimento di Biologia, II Università di Roma, Torvergata, via O. Raimondo, 00173 Roma, Italy

关键词: Ferritin;    Ferroxidase;    Enzyme activity;    Ferritin;    recombinant;   

DOI  :  10.1016/0014-5793(89)81040-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.

【 授权许可】

Unknown