Identity of GD1C, GT1a and GQ1b synthase in Golgi vesicles from rat liver

FEBS Letters

Sandhoff, Konrad¹  Iber, Heinrich¹ 

[1] Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Straße 1, D-5300 Bonn 1, FRG

关键词: Glycosphingolipid;    Ganglioside;    Biosynthesis;    Sialyltransferase;    Cer;    ceramide (N-acylsphingosine);    Gal;    galactose;    GalNAc;    N-acetylgalactosamine;    Glc;    glucose;    NeuAc;    N-acetylneuraminic acid;    UDP-Gal;    uridine 5′-diphosphogalactose;    UDP-GalNAc;    uridine 5′-diphospho-N-acetylgalactosamine;    CDP-choline;    cytidine 5′-diphosphocholine;    CMP-NeuAc;    cytidine 5′-monophospho-N-acetylneuraminic acid;    GlcCer;    glucosylceramide;    Glc1→1Cer;    LacCer;    Galβ1→4Glcβ1→1Cer;    G;    ganglioside;    M;    monosialo;    D;    disialo;    T;    trisialo;   

DOI  :  10.1016/0014-5793(89)81022-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Competition experiments using G_M1b, G_D1a and G_T1b as substrates, and as mutual inhibitors for ganglioside sialyltransferase activity in preparations of Golgi vesicles derived form rat liver, suggested that sialyl transfer to these three respective compounds, leading to gangliosides G_D1C , G_T1a and G_Q1b, respectively, is catalyzed by one enzyme. These results are incorporated into a model for ganglioside biosynthesis and its regulation.

【 授权许可】

Unknown