A class of non‐selective cation channels in human fibroblasts

FEBS Letters

Nobile, Mario²  Mastrocola, Teresa¹  Galietta, Luis J.V.¹ 

[1] Laboratorio di Genetica Molecolare, Istituto G. Gaslini, v. 5 Maggio 39, 16148 Genova, Italy;Istituto di Cibernetica e Biofisica, via Dodecaneso 33, 16146 Genova, Italy

关键词: Cation channel;    Patch-clamp technique;    (Human fibroblast);   

DOI  :  10.1016/0014-5793(89)80925-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Non-selective cation channels were detected in membrane patches of cultured human fibroblasts. The channels had a unitary conductance which ranged from 14 to 25 pS in symmetrical 130 mM NACl and were permeable to both sodium and potassium ions. Open channel probability was dependent either on the membrane potential and the Ca²⁺ concentration on the intracellular side of the membrane. High Ca²⁺ concentrations in the millimolar range were needed to keep the channel active.

【 授权许可】

Unknown